Efeitos do Tramadol, da Acepromazina e da associação de ambos sobre a pressão intraocular e o diâmetro pupilar em gatos saudáveis

Abstract

This study to investigate the effects of the systemic administration of acepromazine, tramadol and the association of both on intraocular pressure (IOP) and pupil diameter (PD) in healthy cats. Cats were randomly allocated into three groups (n=10/each) and treated with acepromazine (AG), tramadol (TG) or acepromazine combined with tramadol (ATG). PD (electronic paquimetry) and IP (applanation tonometry) were assessed before (baseline) and following 15, 30, 60 and 120 minutes of treatments. It was verified that in AG, PD decreased significantly from time point 30 to 120 (P=0.02), but such reduction did not differ significantly from baseline (P=0.89). In TG, PD increased significantly from the first 15 minutes, until the last time point of evaluation (P˂0.001). In ATG, PD increased significantly from time point 30 to 120 minutes, without statistical difference between these periods (P=0.71). Comparisons among groups showed that PD values of TG and ATG were significantly higher than that of AG (P˂0.05). IOP values, on the other hand, did not change significantly among time points and groups (P˃0.05). It is concluded that tramadol alone or in combination with acepromazine does not alter IOP, so it may be considered a satisfactory preanesthetic combination for ophthalmic surgeries in cats. However, such protocols should be avoided in cats with glaucoma, since pre-existing mydriasis may be aggravated.