Viabilidade celular do extrato lipofílico da xylopia aromática (lam.) mart.

Abstract

The plants have medicinal potential and assure several health benefits. For this reason, it is necessary to prove their effectiveness clinically and scientifically. The Xylopia aromatica (Lam.) Mart is a species of tree popularly known as pimenta-de-macaco (monkey-pepper) or pindaíba. With a larger occurrence in cerrado and cerrado field, it blooms up to twice a year, but with greater intensity between September and November. There is a wide interest in this species because it has metabolites such as amides and alkaloids. Due to the presence of these metabolites, those species are related to antiprotozoal activities, with a major effect on Trypanosoma cruzi. The breast cancer is one of the most common neoplasms in women and its effective treatment is challenging. Several cell lines are used to assess the toxic effects of stimuli on cells, including peripheral blood mononuclear cells. Thus, the present study aimed to evaluate the cellular viability of the aromatic Xylopia. The extract of the plant was obtained by rotoevaporation and tested for peripheral blood mononuclear cells at concentrations of 10ng/ml, 100ng/ml and 1000ng/ml. The cells remained viable even after the addition of the extract. It was observed the increase in cell proliferation at the concentration of 10 ng/ml. The lipophilic extract presents a safe margin of use in the concentrations of 10 ng/ml to 1000 ng/ml.