Dispersão sólida como tecnologia para melhoria das propriedades biofarmacêuticas: ênfase em anti-inflamatórios não esteroidais

Abstract

Solid dispersion is a widely used technology for the purpose of improving the oral bioavailability of poorly soluble drugs such as non-steroidal anti-inflammatory drugs (NSAIDs). The objective of this work was to review the literature on the application of solid dispersion technology in improving the biopharmaceutical properties of non - steroidal anti - inflammatory drugs present in solid oral dosage forms. The Web of Science digital platform was the main database used in the period 1961-2018. According to the Biopharmaceutical Classification System (BCS), NSAIDs may be class II or IV, due to low solubility, and with this new technologies, such as solid dispersions, must be employed, in order to optimize the drug in relation to their bioavailability. This is due to the typical properties of the solid dispersions, such as total or partial reduction of drug and crystalline matrix, reduction of drug particle size, being able to reach the molecular level and increase of drug affinity with the aqueous medium resulting from the use of hydrophilic matrices. The studies indicate that solid dispersions are an efficient technology for increasing the solubility of NSAIDs with results well above the conventional formulations available on the market.