Efeitos do tratamento de prednisona em relação aos parâmetros fisiológicos e reprodutivo de ratas wistar prenhes

Abstract

Prednisone is a highly commercialized drug, currently it is the glucocorticoid of choice first for use during pregnancy. For a long time it was believed that its metabolite was inactive by the placenta, not harming the fetus. However, its use has been associated with negative effects in pregnancy, indicating its passage through the placenta. Thus, the study aims to assess the effects of treatment with prednisone on the metabolic and reproductive profile of pregnant rats. Wistar rats distributed in groups were used: CONT (n = 13), rats treated with SyrSpend SF® vehicle before and during pregnancy; PRED1 (n = 14) treated with Prednisone 5mg / ml before and SyrSpend SF® vehicle during pregnancy, and PRED2 (n = 13): treated with Prednisone 5mg / kg before and during pregnancy. The treatment was done orally and daily. Body weight, food and water intake were measured before and during pregnancy. At the end of pregnancy, reproductive indices were calculated. To compare the values found in the parameters, the Student test was used, the percentage values were calculated by analysis of variance (ANOVA), followed by the Tukey test, with 5% significance (p> 0.05). During the previous treatment period, there was a reduction in food consumption by the PRED group, on the other hand, water intake was higher. At the end of pregnancy, the PRED-2 group decreased their body weight compared to the other groups. Reproductive rates were not altered (fertility, pregnancy and childbirth). Thus, it is concluded that the administration of prednisone 5mg / ml before and during the pregnancy of rats, induced changes in gestational development, modifying the analyzed physiological parameters.