Efeito do extrato da folha de Psidium guajava na atividade de fagocitose de células do sangue humano sobre as bactérias Escherichia coli enteropatogênica (EPEC)

Abstract

The Psidium guajava, popularly known as guava tree, is a small tropical tree from the family Mytraceae. It has about 133 genres and more than 3800 species and it can reach 35 meters in height. This tropical tree is used in popular medicine because of your healing effects in the treatment of gastrointestinal disorders, colds and bumps. One of the main causes of gastrointestinal disorders in children is the bacterium Escherichia coli enteropathogenic (EPEC), which is associated with high rates of infant mortality in developing countries. It was evaluated the effects of Psidium guajava on blood phagocytes for antibacterial action over the bacterium Escherichia coli enteropathogenic (EPEC) because of the necessity of new alternatives to treat disorders caused by this bacterium plus the healing effects of the Psidium guajava. Extraction and preparation of the extract of Psidium guajava leaf in concentrations 200 mg/mL, 200 µg/mL, 200 ng/mL and 200 pg/mL to perform the viability tests, phagocytosis, superoxide dismutase enzyme (SOD) and rheology the blood cells together with the bacterium Escherichia coli enteropathogenic were incubated with the extract in each of this concentrations. The different concentrations of Psidium guajava showed immunomodulatory effects over blood cells function, stimulating phagocytosis and modulating the function of the superoxide dismutase enzyme (SOD). In concentrations 200 mg/mL and 200 µg/mL, the extract modified blood viscosity. However, in concentrations 200 ng/mL and 200 pg/mL the blood viscosity was the same as the normal one. The Psidium guajava’s extract in a certain concentration has antibacterial effects and does not change the physiological behavior of human blood.