Efeitos da resistina sobre atividade funcional de células do colostro de mães diabéticas

Abstract

Diabetes mellitus is caused by a metabolic disorder with different etiologies, the main characteristic of the pathology is chronic hyperglycemia resulting from the functional effects on the action and/or secretion of insulin, which leads to insulin resistance in the individual. When plasma glucose concentrations are not regulated, they lead to the development of secondary diseases. The pathology in the individual develops chronic inflammation, and can be classified into: Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Gestational Diabetes Mellitus and Diabetes influenced by several factors. During pregnancy of mothers with type 2 diabetes mellitus, glucose levels may be unbalanced and change the concentrations of bioactives, nutrients and leukocytes normally present in colostrum and breast milk, which directly influence the health and protection of the newborn. Resistin is a protein that is normally found in blood and breast milk. A cohort study was carried out, taking into account the glycemic status prior to pregnancy. In the study, the influence that resistin has on colostrum mononuclear cells was observed, evaluating the phagocytic activity and the microbicide index between diabetic mothers and healthy mothers. It was possible to observe that diabetic colostrum favors the amount of immune defense cells due to inflammatory stimuli due to the pathology and the microbicidal activity may be satisfactory. With the results, it was possible to conclude that: the percentage of phagocytosis was higher in the control group than in the diabetic group when stimulated with resistin. A high level of phagocytosis was observed in the diabetic group with or without resistin. The diabetic group had a lower microbicide index compared to the eutrophic group when stimulated by resistin. Therefore, resistin was able to immunologically modulate human milk colostrum.