Impotência sexual: análise qualitativa de tratamento utilizando raízes de Fridericia dichotoma

Abstract

Currently, pharmacological treatments for erectile dysfunction (ED) contain contraindications and there are reports of visual and cardiovascular disorders. Therefore, treatment alternatives are being investigated, including the use of natural products and their secondary metabolites that may represent a solution for many ED patients. There is scientific evidence that alkaloids can be useful for the treatment of impotence and erectile dysfunction. The present work aims to determine the presence of alkaloids in the roots of the Fridericia dichotoma species and its relationship with the attributed pharmacological activity, contributing to support the popular use of F. dichotoma extracts as a remedy for erectile dysfunction. For this, an acid-base extraction methodology was used associated with chromatographic and classical phytochemical experiments with the alkaloid fractions obtained. In the first step, the presence of alkaloids in the fractions was evaluated by Thin Layer Chromatography (TCD) and visualized in a UV lamp and revealed in Dragendorff reagent. The presence of alkaloids was evident only in the chloroform fraction 1. In the second stage of alkaloid analyses, using a phytochemical method of analysis according to Matos (1997) using Hager, Mayer and Dragendorff reagents as a developer. The tests were considered positive through color variation and/or the appearance of precipitate in the reaction medium. Being positive for alkaloids in all fractions tested. We can therefore conclude that the presence of alkaloids in the species Fridericia dichotoma, indicate an interesting therapeutic potential and could justify its populares use of the plant in the treatment of sexual impotence, requiring further studies to investigate the biological/pharmacological activities attributed to the species.