Revisão e estudo de complexos metálicos com potencial antifúngico contra cepas de Candida albicans

Abstract

Candidiasis, caused mainly by Candida albicans yeast, is a pathology that affects a significant amount of people in the world, mainly women, thus being a public health issue. In addition, clinical practice has found it difficult to treat candidiasis for two reasons: the multidrug resistance associated with the exacerbated use of available drugs and the high number of side effects caused by current antifungal drugs. In this scenario, this work is a literature review on the antifungal activity of metal complexes against C. albicans, since they are extensively studied for their varied applications in health sciences, as an object of study in the area of inorganic chemistry, in the subareas of bioinorganic chemistry and pharmaceutical chemistry. Data collection was carried out using the Capes, PubMed, Cochrane Reviews and Virtual Health Library (BVS) databases. The results obtained through bibliographic surveys show the importance of studies of metal complexes against the strain of C. albicans, which have promising inhibitory activities, and in some cases, with Minimum Inhibitory Concentration (MIC) values lower than 20µg/mL, highlighting the activity performed by ruthenium complexes and Schiff bases when coordinated to metallic ions, which arouses great interest in a future study of a complex of this metal with a Schiff base in its coordination site.