Compostos de coordenação como potenciais agentes quimioterápicos no tratamento da doença de Chagas

Abstract

Chagas disease is a parasitic disease resulting from infection promoted by the hemoflagellate protozoan Trypanosoma cruzi. This parasitic disease represents a major public health problem in tropical countries. Available chemotherapy with benznidazole and nifurtimox has serious limitations and serious side effects. Against this background, the development of trypanocide drugs is of great need. In recent years, interest in metal-based drugs with potential applications has been in a variety of therapeutic areas, especially within the bioinorganic community. Thus, the pursuit of an alternative chemotherapy was proposed by the use of metal complexes that already have anti-infective characteristics. This review monograph aims to consider and analyze the antiparasitic activity of some compounds based on ruthenium, vanadium, palladium, copper and gold metals; as well as their mechanisms of action denoting the considerations in the mechanisms of action as promising drugs to be used against Chagas disease.