Síntese, estudo das transições eletrônicas e investigação antibacteriana de um complexo de íon rutênio (II) coordenado ao flavonoide rutina frente a Staphylococcus aureus

Abstract

It is important to emphasize the emotion that metallic complexes present to society and, in particular, to the medical segment, since these have been used in medicine for centuries. The present study aims at the synthesis, characterization and study of electronic transitions and the in vitro antibacterial evaluation of a metal complex containing ruthenium (II) ion coordinated to the flavonoid rutin, with the general formula cis[Ru(phen)2(rut)] PF6 (Ru= Ruthenium (II), phen= 1,10-phenatroline and rut= rutin). The methodology adopted was divided into two stages, the theoretical stage, where the bibliographic study of the theme was carried out, and the experimental stage, in which the product obtained was characterized by means of spectroscopic techniques of Absorption in the Infrared Region (IR - FTIR), in the Ultraviolet-Visible Region (UV-vis) and 1H Nuclear Magnetic Resonance; the structure of the compound was also investigated using the method of elemental analysis of C, H, N and optical emission spectrometry. Being possible, at the end of the application of the mentioned techniques, the language of the structure of the metallic complex synthesized, which is pure. Cytotoxicity assays and antibacterial tests against Staphylococcus aureus bacteria were also performed and the results confirmed that the complex does not present cytotoxicity to human healthy cells.