Introdução ao estudo de compostos de coordenação de vanádio e zinco como alternativa no tratamento de diabetes mellitus

Abstract

Diabetes mellitus (DM) is considered the disease of the 21st century, either because of the constant increase in its prevalence or because it requires incisive expenditures by the governments of countries around the world. Inorganic Chemistry appears as a key element in the fight against this disease, presenting studies of metals with insulinmimetic potential aiming at neutralizing this constant increase. DM is characterized by abnormalities in the metabolism of proteins, carbohydrates and lipids, caused by defects in insulin action or insulin secretion. There are two main types of DM: type 1 DM that occurs when the body begins to destroy pancreatic β cells, while type 2 is related to aging, obesity, lifestyle and extreme factors. The treatment of this disease is performed through the application of exogenous insulin subcutaneously (type 1) and through drugs (type 2). Medicinal Inorganic Chemistry plays a fundamental role in the future of disease treatment, as it studies the role of metals in the diagnosis and treatment of various diseases, including DM. In the present work, it was done from a brief literature review in the search for coordination compounds, especially Zinc (II) and Vanadium (IV) complexes capable of helping in the treatment of human Diabetes Mellitus, as well as analyzing the future perspectives of these metal drugs.