Análise laboratorial da função renal e hepática em cães induzidos com superdose de dexmedetomidina

Abstract

In therapeutic doses, dexmedetomidine (DEX) is used for analgesia and sedation. However, when overdoses are applied, there are no reports on its effects on renal and hepatic physiology. The present study aimed to compare the hematological and biochemical profiles of dogs, before and after the administration of DEX overdoses for semen collection. Fifteen healthy dogs, aging from 2 to 5 years old, and weighing between 5 and 10 kg were submitted to semen collection after DEX (15 µg kg-1) and ketamine (3 mg kg-1) injection. Blood samples were collected before (T0) and after 20 (T20), 40 (T40) and 60 (T60) minutes, and 48 hours (D2) of the administration. Serum urea, creatinine, albumin, calcium, phosphorus, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and serum aspartate transaminase (AST) were measured. At T0 and D2 a complete blood count was performed. After analysis, urea (P = 0.009), creatinine (P = 0.002), albumin (P = 0.0001), ALT (P = 0.029) and phosphorus (P = 0.00000023) serum concentrations presented statistical significance between time points. Complete blood count showed significant differences on total number of leukocytes (P = 0.0006), neutrophils (P = 0.002), lymphocytes (P = 0.03) and monocytes (P = 0.03) between T0 and D2. In conclusion, in overdoses, dexmedetomidine should be used with caution once it causes transitory renal injury.