Parâmetros reológicos em sangue humano com leucemia

Abstract

The importance of blood and leukocytes in the human body, highlighting leukemia, as a disease that affects the stem cells responsible for blood production, with a special focus on Chronic Myeloid Leukemia (CML). The types of leukemia, the main symptoms and laboratory analyzes associated with the diagnosis are described. The present work aims to evaluate the rheological and hematological parameters of the blood of patients with leukemia. For this, blood samples were collected from four people at the Dr. Arnulfo da Cunha Coutinho Municipal Laboratory, one with previously diagnosed Leukemia (CML), and three individuals without comorbidities. Hematological tests were carried out in the Municipal Laboratory and then rheological experiments were carried out with prior dilution, containing 100µL of blood with 900µL of Saline Solution at a concentration of 0.9%. Samples were applied to the reading plate, the samples were analyzed by the Modular Compact Rheometer – MCR 102 (Anton Paar GmbH, Ostfildern, Germany) in the Chronoimmunomodulation Laboratory at UFMT - CUA. It was observed at the end of the study that leukemia can alter the rheological patterns of the blood, the main cause being the hematological changes caused by the disease. Such changes are related to the shear rate (deformation) and not viscosity. The study of blood rheological parameters in leukemia can be an important diagnostic and monitoring tool.