Ovary mucinous anaplastic carcinoma in a puma (Puma concolor)

Abstract

An adult female puma (Puma concolor) was referred to Veterinary Hospital service from Federal University of Mato Grosso (UFMT) for necropsy evaluation. The patient had previous history of anorexia, ataxia, dyspnea and ascites for 3 months, but there was no information on her reproductive history. At necropsy an approximately 43 cm in diameter, friable, irregular, multilobulated mass was observed in the right ovary. Microscopically, the nodules showed a pleomorphic pattern composed of oval or fusiform cells with a diffuse irregular growth pattern. Neoplastic cells were also observed in the liver. The nodules were positively stained in the histological technique Alcian Blue and immunohistochemistry positive for pan cytokeratin, vimentin and S-100. These nodules were negative for inhibin 39 alfa (INH-), calretinin, melan A and α-smooth muscle actin. Based on the microscopical and immunohistochemistry features, a diagnostic of mucinous anaplastic carcinoma was made.