Uso de biomarcadores : CK-NAC, CK-MB e Troponina I em cães com doença cardíaca

Abstract

The use of cardiac biomarkers for clinical diagnosis has increased, however, in veterinary medicine the use still restricted to research. The aim of this study was to evaluate the reliability of serum creatine kinase values, creatine kinase MB fraction and troponin I-heart fraction (Tnlc) on heart disease correlated with the presence or absence of clinical signs. We evaluated 45 animals of different breeds, sex and age, divided into two groups. The group I have 15 healthy dogs without changes in radiography, electrocardiography and echocardiography. The group II was composed by 30 dogs with clinical signs of heart disease and change in at least one of the tests used for assessment. The age ranged from one to 11 years in group I (control) and 2-17 years in group II. The most frequent clinical sign was coughing, followed by tiredness. The reference values for CK-MB in group I ranged 95-262 U / I with an average of 157 ± 49.99 and in group II (heart disease) ranged 74-787 U / L with a mean of 187.46 ± 161 10, but there was no significant difference (p = 0.05) between groups for CK-MB and CK-NAC values. The rapid test troponin I - Heart fraction (Tnlc) was negative for the 45 animals in the study. In this research, the CK-MB was not a good indicator of heart disease, but are recommended further analysis with an increase in the number of dogs.