Efeitos do peptídeo semelhante ao glucagon-1 (GLP-1) sobre a ingestão alimentar de ratas submetidas à restrição proteica

Abstract

Moderately hypoproteic diet increase food intake and GLP-1 is a physiological regulator of food intake and appetite. Therefore, the present study evaluated the influence of this hormone on the dietary pattern of rats subjected to protein restriction. Female Wistar rats were divided into four groups according to the type of received diet and treatment with GLP-1 receptor agonist (Ex-4): 1) Control; 2) Control Agonist; 3) hypoprotean; 4) hypoprotean agonist. Irrespective of treatment with GLP-1 receptor agonist, the hypoproteic rats showed significantly greater food intake on day 1 of treatment and lower at day 6 of treatment compared to control rats. However, food intake relative during meal test was higher in rats of hypoproteics groups compared to control groups of rats. The plasma concentration of GLP-1 and gastric emptying were similar in the four groups studied. The hypoproteic diet increased the duration of the behavior "food intake", independent Ex-4 use. The frequency behavior of "self-cleaning" was lower in the group without hypoprotean Ex-4 compared to control in the same condition. Ex-4 increased this behavior only in hypoprotean group, which started to show similar frequency to the control treated with former 4. The drug decreased the duration and frequency of food intake, increased the duration and frequency of feeding operation and duration of intake of water, regardless of nutritional status. Therefore, GLP-1 does not influence the animal feed standard maintained a low protein diet.