Avaliação dos aspectos reológicos do fruto de dillenia indica e seus efeitos sobre a atividade funcional de células do sangue humano

Abstract

Dillenia indica popularly known as elephant apple is a tree with a large crown, from the family dilleniceae, native to tropical Asia. The fruit contains fleshy petals that involve seeds, the fruits are used in folk medicine to treat muscle pain, in case of inflammation and analgesics in cases of rheumatism and osteoarthritis. This work aimed to evaluate the rheological and oxidative aspects of the fruit on the functional activity of human blood cells. The extract of the fruit was extracted at concentrations of 10 ng / ml and 100 ng / ml and later the rheological aspects and cellular behavior were verified with the presence of the extract. It was observed that the fruit extract, regardless of concentration, there was no change in the flow curve. The blood viscosity was higher when the blood was incubated with the fruit at a concentration of 100 ng / ml. Cell viability in the presence of the fruit extract was greater than 95% and the fruit extract was able to increase phagocytosis. When these cells were incubated with the bacteria (EPEC) and treated by the extract at a concentration of 100 ng / ml, there was a tendency to reduce SOD concentration. These data suggest that the extract of Dillenia indica was able to modulate the functional activity of blood cells, especially when in the presence of EPEC.