Aterosclerose associada a hipotireoidismo em um canino : relato de caso

Abstract

A case of diffuse atherosclerosis associated with hypothyroidism in a dog in the municipality of Taubaté, in the state of São Paulo, is described. A 9-year-old Basset Hound canine weighing 34 kilos was necropsied after death with no apparent cause. Complementary examinations of hemogram, biochemistry, x-ray, electrocardiogram and ultrasonography were provided in order to assist the diagnosis. During the necropsy examination, outbreaks of alopecia and scaly skin lesions on limbs and overweight were observed externally. In the macroscopic examination generalized lymphadenomegaly; Small, pale-colored thyroids surrounded by abundant adipose tissue; Heart slightly bulging, coronary arteries evident engorged and with stiffened wall; Aortic abdominal and iliac arteries with thickened and stiffened surface. Organ fragments were collected, fixed to 10% formalin and routinely processed for the production of histopathological slides. The laminae were examined under light microscopy by hematoxylin and eosin staining, where it was observed a reduced size thyroid, with loss of follicles and replacement by adipose tissue; Arteries with accumulated lipid globules in the cytoplasm of smooth muscle cells and macrophages (foam cells), in the middle and intima tunics, accumulation of cholesterol crevices, proliferation of fibrous connective tissue with foci of mineralization. Diagnosis was based on clinical history, necropsy findings and histopathology.