Avaliação de superóxido dismutase e melatonina no colostro e plasma de mães diabéticas com obesidade

Abstract

Chronic diseases influence the constituents of breast milk, so it affects fetal and maternal health. The objective of this work was to evaluate the influence of obesity and diabetes on biochemical and hormonal parameters in maternal blood and colostrum. For the composition of the groups, women were initially classified according to body mass index (BMI) as eutrophic (BMI between 18.5 to 24.9 kg/m2) and obese (BMI≥30 kg/m2). They were also evaluated by the glycemic mean, being considered normoglycemic (glyce CuZn-SOD was quantified by reducing nitroblue tetrazolium and melatonin by the ELISA method. It was observed that in the colostrum of obese mothers, hyperglycemia reduced the concentration of CuZn levels. In plasma, hyperglycemia was able to reduce the concentration of CuZn These results suggest that the chronic inflammation caused by obesity, and the hyperglycemia caused by diabetes, alters biochemical and hormonal components present in colostrum and maternal plasma.