Potencialidades de compostos de coordenação no tratamento da malária

Abstract

The Evolution of science has a fundamental role in the search for effective solutions to combat tropical diseases, corroborating the evolution of studies of medicinal inorganic chemistry and its scientific advances as the discovery of treatments from the coordination compounds. Therefore, studies of new compounds are necessary, among them the coordination compounds have presented interesting biological activities, fungicide, bactericidal and antiviral activity. Reports in the literature show that coordination compounds may be an interesting alternative for antiparasitic therapy against Malaria and other tropical diseases. The objective of this monograph is to review the literature and evaluate the potential of metallic compounds containing ruthenium, rhodium and gold ions in the mechanism of action in combating Malaria, and with a relevant contribution to the treatment of other parasitic diseases. The main coordination compounds that through research have become effective in the treatment of antimalarial diseases will be discussed.