Efeitos da colostrinina sobre os parâmetros reológicos do colostro de mães sobrepeso e obesas

Abstract

The World Health Organization (WHO) defines obesity and overweight as a disease caused by excess body fat, which causes damage to the health of the individual, such as cardiopathy disease. There are estimates that there are around 1 billion people in the world who are overweight, and that by the year 2025, about 167 million people will be overweight or obese. Maternal obesity can generate several complexities throughout pregnancy, such as the incidence of pre-eclampsia and the onset of gestational diabetes mellitus (GDM) in women with high pre-gestational BMI. Overweight and obese individuals often have imbalances in the levels of lean mass, fat mass, lipids and lipoproteins, negatively favoring cell damage. Breastfeeding represents one of the important periods in the female reproductive process, ensuring benefits for both the mother and the newborn. Colostrum is the first fluid produced by the mother, presenting as one of the main immunological components, the secretory IgA. Colostrinin is a polypeptide complex rich in proline (PRP) and nanopeptides (NP), which has immunoregulatory properties, exhibit psychotropic characteristics, where together they act in cellular and humoral immune responses. Rheology is the science that studies the deformation and flow of solid bodies or fluids, and is defined as the study and deformation of matter, where greater or lesser fluidity occurs, and viscosity, the measure of fluid resistance to displacement. Thus, in the present study, we sought to evaluate the effect of colostrinin on the rheological parameters of milk from obese and overweight mothers. Colostrum samples were collected from 15 mothers, 5 eutrophic mothers, 5 overweight mothers and 5 obese mothers. The rheological parameters were determined in the presence or absence of Colostrinin (100 ng.mL1) by the cone rheometer and the data obtained by the RheoPlus software. The results of this study allowed the following conclusions, where the colostrum of eutrophic, overweight and obese mothers present a non-Newtonian thixotropic behavior, the colostrum flow curves demonstrated an increase in the statistical differences in the values of shear rate between eutrophic and overweight, colostrum viscosity curves showed a decrease in statistical differences only in shear rate values between eutrophic and overweight mothers, colostrinin did not alter non-Newtonian thixotropic behavior in all studied groups and there were differences in flow curves and of viscosity when treated by colostrinin in colostrum from eutrophic and overweight mothers. Therefore, colostrinin was not able to restore the rheological parameters of deformation and viscosity of colostrum from overweight and obese mothers.