O efeito do extrato bruto do bacupari em células fagocíticas do sangue periférico humano

Abstract

Despite being used for several years to benefit human health, the known medicinal plants still need to have their therapeutic potential explored. It is very important to preserve these documents so that there is no loss of medicinal learning over time due to the respective environmental changes and technological advances. The use of various medicinal plants is common, where, subsequently, their active compounds have the potential to be used in the treatment of diseases caused by bacteria. The knowledge that antimicrobial resistance is growing in relation to chemically synthesized drugs leads to the revelation of new alternative methods to treat infections derived from bacteria. Garcinia brasiliensis, which is known as bacupari, is used for medicinal purposes because it has antimicrobial activity against Gramnegative and Gram-positive bacteria. The study in question had as general objective to evaluate the activation of human peripheral blood phagocytes for Enteropathogenic Escherichia coli (EPEC) in the presence of bacupari and as a specific objective to evaluate the cytotoxic activity of bacupari, phagocytic activity for EPEC in the presence of bacupari and bactericidal activity from bacupari to EPEC. The objectives were evaluated through the use of bacupari crude extract at a concentration of 100 nanograms per ml using the Acridine Orange method. The results obtained reveal that the bacupari crude extract is not cytotoxic to mononuclear cells, in addition to helping cells in the phagocytosis of EPEC and in the death of these microorganisms.