Efeitos da colostrinina sobre os parâmetros reológicos do leite de mães diabéticas

Abstract

Diabetes is an important public health problem, especially in developing countries with the highest prevalence and incidence rates. The impact of the disease stems not only from its clinical condition directly related to hyperglycemia but mainly from functional changes that occur in different organs and systems, resulting from chronic metabolic control of proteins and lipids. Breastfeeding protects the newborn against acute and chronic diseases, such as diabetes mellitus, obesity, diarrhea, and airway infection. Human milk is rich in important bioactive components. Among these, Colostrinin is a proline-rich polypeptide capable of regulating resistin and is considered a potential use in diabetes therapy and prevention. It is known that exposure of cells to Colostrinin decreases the levels of active oxygen metabolites, regulates the pathway of the capable ones that are mediators of apoptosis and necrosis, and inhibits proinflammatory cytokines. However, studies on the biological effects of Colostrinin on the milk of mothers with diabetes are still needed. Rheology is the science that studies the deformation or flow of materials. Through rheological properties, one obtains information about how a material reacts when subjected to mechanical stress, which is the expression of its structure resulting from its chemical composition, the different interactions between its various components, and the processing it has undergone. Thus, the objective will be to evaluate the effect of Colostrinin on the rheological profile of milk of mothers with diabetes. Colostrum samples from normoglycemic, hyperglycemic, and diabetic mothers will be collected. The cone rheometer will determine the rheological parameters and the data obtained by the RheoPlus software. The colostrum of normoglycemic, hyperglycemic, and diabetic mothers demonstrated thixotropic non-Newtonian rheological behavior. The flow and viscosity curves of the colostrum showed significant differences in the shear rate values among normoglycemic, hyperglycemic, and diabetic mothers. Colostrinin corrected the rheological parameters of deformation and viscosity of colostrum of hyperglycemic and diabetic mothers. These data suggest that hyperglycemia increases colostrum viscosity and that colostrinin was able to restore colostrum rheological parameters from mothers with diabetes.