Atividade reológica do extrato hidroalcoólico de Vernonia condensata Baker em sangue periférico humano

Abstract

The use of medicinal plants for the treatment of numerous pathologies has always been recurrent in Brazil. The boldo-baiano, or popularly known as alumã or figátil, is among those species that have an effect of analgesic, antibacterial, antifungal, antiulcerogenic properties, among others. Therefore, the present work aims to analyze the rheological parameters of human peripheral blood being treated with hydroalcoholic extract of Vernonia condensata Baker. For this, with the consent of all, human blood was collected from five healthy individuals between 19 and 25 years old, their samples were divided into two groups: one containing 800 µL of blood with 50 µL of boldo-baiano extract (Vernonia condensata) at a concentration of 100ng/mL and the control group also containing 800 µL of blood with 50 µL of distilled water. Then, the samples were analyzed by the Modular Compact Rheometer – MCR 102 (Anton Paar GmbH, Ostfildern, Germany). It was observed that the extract of V. condensata at a concentration of 100ng/mL did not significantly alter the rheological parameters of blood viscosity and flow curve. Between the blood treated and the blood not treated with the extract, the shear rate parameter (ẏ) of 1.3118/s and a viscosity (η) of 0.003 Pa.s were obtained. As for the flow curve, there was a difference in the deformation rate of 1.3118/s, differing only 0.01/s from the blood treated with Vernonia condensata extract, thus making it a biocompatible extract for the material used.