Análise reológica do sangue de indivíduos positivados para sífilis

Abstract

Syphilis is an infectious disease, caused by the etiological agent Treponema pallidum, transmitted mainly through sexual contact, or through vertical transmission during pregnancy. Infectious diseases have been associated with rheological changes in the blood. Understanding the rheology of human blood has been the subject of research for the most diverse pathologies, considering that changes in the rheological parameters of blood in the presence of the disease can be a determining factor in its progression. The objective of the present study was to evaluate the rheological behavior of blood in patients positive for syphilis. A total of 20 samples were used. 10 samples of clinically healthy individuals, aged 19 to 50 years, with a negative VDRL test for syphilis. 10 blood samples with a positive VDRL test, totaling 10 samples, all individuals were protected as to their identity, with total confidentiality and professional ethics in the handling of the samples. Blood was obtained by venipuncture for rheological analysis using a Modular Compact Rheometer. Model MCR 102 (Anton Paar) Chronoimmunomodulation Laboratory at UFMT-CUA. Statistical analysis was determined by Student's t-test or One-Way ANOVA test and Tukey's post-test. Values of p<0.05 were considered statistically significant. It was observed that the blood in both groups presents a parabola-shaped curve, non-linear ascending, characterizing non-Newtonian fluids. It was possible to observe a significant decrease in the blood shear rate of individuals positive for the presence of syphilis in relation to negative individuals (950m vs 1400m), and consequently a significant increase in blood viscosity for these same individuals (0.00526m vs 0 ,00320m). It is concluded that syphilis, a highly infectious disease, alters rheological parameters, decreasing the shear rate and increasing the viscosity of the blood of these individuals.