Anomalia de Pelger-Huët em gato : relato de caso

Abstract

This study aimed to describe a case of Pelger-Huët anomaly in a two-month-old mixedbreed cat treated at the Veterinary Hospital of the Federal University of Mato Grosso with complaints of difficulty defecating, eye secretion and delayed development. The blood count demonstrated leukocytosis due to neutrophilia with marked degenerative left shift and toxic changes in neutrophils, in addition to reactive lymphocytes, activated monocytes and thrombocytosis. The predominance of hyposegmented granulocytes with coarse and mature chromatin suggested the diagnosis of Pelger-Huët anomaly (PHA). The blood count was repeated six times over a period of 52 days and the morphology of the granulocytes remained even after there was no longer any evidence of inflammation. Hypolobulated monocytes with hypercondensed chromatin and absence of Barr bodies were also observed. The case represents a presumably congenital Pelger-Huët anomaly, exhibiting the cellular morphology characteristic of this condition and the absence of factors indicating acquired APH. This is a disorder that can affect different animal species and breeds, and should be considered a differential diagnosis of marked left shifts and demonstrating the importance of cytological evaluation carried out by the clinical pathologist.