Avaliação do perfil bioquímico de ratos Wistar obesos tratados com óleo de baru (Dipteryx alata): um estudo intergeracional

Abstract

Obesity is influenced by intergenerational factors, such as maternal obesity. Existing treatments have limitations, and phytotherapy emerges as an alternative. However, there are no studies on the use of Dipteryx alata (baru) in this context. The objective of this study was to evaluate the physiometabolic parameters of obese rats subjected to treatment with baru nut oil. A total of 29 male and female Wistar rats, offspring of obese mothers, were used and treated daily via oral gavage, divided into the following groups: control (C, treated with filtered water, N=9); DA125 (D. alata, treated with baru oil at 125 mg/kg, N=10); and DA250 (D. alata, treated with baru oil at 250 mg/kg, N=10), for 28 days. Weekly measurements included body weight, nose-toanus length, solid food intake, and liquid consumption. After the treatment period, the animals were euthanized for blood collection and serum separation for biochemical analyses, and organs (heart, liver, kidneys) and tissues (periepididymal and periovarian fat) were collected to assess relative weight. Data were analyzed using ANOVA followed by Tukey's multiple comparisons test, considering statistical significance at p<0.05. It was found that the DA250 group showed a significant increase on day 7, compared to the control group and its own baseline (day 0), followed by a reduction on days 14 and 21 compared to day 7. In the DA125 group, a decrease was observed on day 14 compared to day 7, followed by an increase on day 28 compared to days 0, 14, and 21. The control group, in turn, showed a significant increase on day 28 compared to day 21. These findings indicate potential safety at the established doses and suggest that the oil acts as a regulator of energy metabolism. Therefore, further studies are needed to understand its mechanisms of action and long-term effects.