Leishmaniose visceral : alterações oftálmicas em cães

Abstract

In visceral leishmaniasis ocular signs are common and include keratoconjunctivitis sicca, lymphoplasmocytic uveitis or granulomatous addition to conjunctivitis. This study aimed to evaluate clinical and morphologically as ophthalmic disorders in dogs reagents to Leishmania chagasi and analyze the relationship with the Protein C Activity Reactive, and antibody presence and antigens in the samples serum and aqueous humor. Of the 18 dogs studied, the most prevalent ophthalmic changes were the CCS (72.72%), the corneal edema (30%) and uveitis (18.18%). All dogs were sororregantes and two samples of aqueous humor were detected antibodies against L. chagasi. In PCR, on 10 samples from buffy coat and four aqueous humor was amplified DNA L. chagasi. In the statistical analysis, a negative correlation was observed (p <0.05) between the concentration of C-reactive protein and serum antibodies and aqueous humor. Morphological alterations were lacrimal adenitis and mild and moderate focal lymphoplasmocytic conjunctivitis (16.16%) without what if they noticed in the eye and attachments globe, structures compatible with Leishmania sp. amastigotes. These changes may be associated with a deposit of immune complexes due to the presence of specific antibodies anti-Leishmania.